abstract：:We examined antioxidant activity of cabergoline, a dopamine agonist, during the aerobic oxidation of phosphatidylcholine liposomes at 37 degrees C. Cabergoline retarded the oxidation initiated with a lipid-soluble initiator significantly better than that with a water-soluble initiator, suggesting that cabergoline loca...

journal_title：Neurological research

authors： Sohmiya M,Tanaka M,Okamoto K,Fujisawa A,Yamamoto Y

更新日期：2004-06-01 00:00:00

abstract：:Endovascular reconstruction of basilar artery (BA) apex aneurysms has been augmented by adjunctive techniques such as balloon and stent assistance. We present three cases of a wide-necked BA apex aneurysm involving the bilateral P1 segments of both posterior cerebral arteries (PCAs) treated by placement of BA to PCA s...

journal_title：Neurological research

authors： Perez-Arjona E,Fessler RD

更新日期：2004-04-01 00:00:00

abstract：:We describe the technique of percutaneous carotid artery stent placement with distal protection in a patient in whom marked innominate artery ectasia prevented transfemoral access to the right common carotid artery. After induction of general anesthesia, ultrasound was used to guide direct puncture of the common carot...

journal_title：Neurological research

authors： Perez-Arjona EA,DelProsto Z,Fessler RD

更新日期：2004-04-01 00:00:00

abstract：:The elements of peripheral nerve regeneration comprise a complex combination of nerve growth, muscle satellite cells proliferation and differentiation and vessel growth. There is also increasing evidence that growth factors may act at multiple levels in the regenerative response. One such factor affecting multiple cel...

journal_title：Neurological research

authors： Rabinovsky ED

更新日期：2004-03-01 00:00:00

abstract：:Compromise of blood flow to the brain leads to cerebral ischemia, which if left untreated may even result in cerebral infarction. This has been the main cause of major morbidity and mortality over the years in the US and around the world. Cerebral ischemia to the posterior fossa is more critical and difficult to treat...

journal_title：Neurological research

authors： Misra M,Alp MS,Hier D,Ausman JI

更新日期：2004-01-01 00:00:00

abstract：:Recovery of motor function following stroke is believed to be supported, at least in part, by functional compensation involving residual neural tissue. The present study used a rodent model of focal ischemia and intracortical microstimulation (ICMS) to examine the behavioral and physiological effects of cortical stimu...

journal_title：Neurological research

authors： Kleim JA,Bruneau R,VandenBerg P,MacDonald E,Mulrooney R,Pocock D

更新日期：2003-12-01 00:00:00

abstract：:Complete thrombosis followed by recanalization of giant aneurysms is an infrequent process that has been exceptionally mentioned in relation to nongiant saccular aneurysms. A 25-year-old male presented with a right temporal hematoma and associated subarachnoid hemorrhage. Cerebral angiography revealed a small blister-...

journal_title：Neurological research

authors： Cohen JE,Rajz G,Umansky F,Spektor S

更新日期：2003-12-01 00:00:00

abstract：:This study comprises scientific-theoretic fundamental investigations of laserneedle technology, a new and painless method of acupuncture stimulation. Laserneedles are not inserted in the skin, but are merely placed on the surface of the acupuncture point. The study documents the significant changes in peripheral micro...

journal_title：Neurological research

authors： Litscher G

更新日期：2003-10-01 00:00:00

abstract：:Recent evidence indicates that different vascular risk factors are present in Alzheimer's disease (AD) and other prevalent dementia types probably contributing to deterioration of cerebrovascular function, thus enhancing neurodegeneration and premature neuronal death due to a reduction in brain perfusion. Brain blood ...

journal_title：Neurological research

authors： Cacabelos R,Fernández-Novoa L,Lombardi V,Corzo L,Pichel V,Kubota Y

更新日期：2003-09-01 00:00:00

abstract：:Decreased metabolic rate may precede cognitive impairment in Alzheimer's disease (AD) and is thus an early occurring hallmark. Several observations in post-mortem brain indicate that activated neurons are better able to withstand aging and AD, a phenomenon paraphrased by us as 'use it or lose it'. Moreover, a number o...

journal_title：Neurological research

authors： Swaab DF

更新日期：2003-09-01 00:00:00

abstract：:The purpose of this prospective observational study was to investigate the relation between the frequency of critical neuromonitoring parameters (brain tissue pO2, (PtiO2) < or = 10 mmHg, intracranial pressure (ICP) > 20 mmHg, cerebral perfusion pressure (CPP) < or = 70 mmHg) and outcome after severe aneurysmal subara...

journal_title：Neurological research

authors： Meixensberger J,Vath A,Jaeger M,Kunze E,Dings J,Roosen K

更新日期：2003-07-01 00:00:00

abstract：:The aim of this study was to examine the pre-operative clinical and neuromonitoring courses in patients with a decompressive craniectomy to assess and to compare clinical and neuromonitoring signs indicating extensive cerebral edema. We conducted a retrospective analysis of the clinical signs and courses of simultaneo...

journal_title：Neurological research

authors： Strege RJ,Lang EW,Stark AM,Scheffner H,Fritsch MJ,Barth H,Mehdorn HM

更新日期：2003-07-01 00:00:00

abstract：:We examined regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO2) in 10 patients with progressive dementia and amyotrophic lateral sclerosis (DALS), in 21 patients with classical amyotrophic lateral sclerosis without dementia (ALS), and in 17 controls. The mean rCBF and rCMRO2, especially in the anterior ...

journal_title：Neurological research

authors： Tanaka M,Ichiba T,Kondo S,Hirai S,Okamoto K

更新日期：2003-06-01 00:00:00

abstract：:Monitoring of brain tissue oxygenation (ptiO2) enables early diagnosis of secondary cerebral ischemia and may guide a cerebral perfusion pressure (CPP) orientated therapy. The purpose of our study was to explain the concept of ptiO2-autoregulation, defined as the ability of the brain to maintain ptiO2 despite changes ...

journal_title：Neurological research

authors： Soehle M,Jaeger M,Meixensberger J

更新日期：2003-06-01 00:00:00

abstract：:Endolymphatic sac tumors are rare, low-grade adenocarcinomas of the petrous bone. These tumors are highly vascularized and surgical removal is often challenging. We present a staged endovascular-neurosurgical approach consisting of stent-assisted angioplasty of the petrous carotid, selective endovascular embolization ...

journal_title：Neurological research

authors： Cohen JE,Spektor S,Valarezo J,Fellig Y,Umansky F

更新日期：2003-04-01 00:00:00

abstract：:Vestibular neuritis (VN) rapidly damages unilateral vestibular periphery, inducing severe balance disorders. In most cases, such vestibular imbalance is gradually restored to within the normal level after clinical therapies. This successive clinical recovery occurs due to regeneration of vestibular periphery and/or ac...

journal_title：Neurological research

authors： Kitahara T,Kondoh K,Morihana T,Okumura S,Horii A,Takeda N,Kubo T

更新日期：2003-04-01 00:00:00

abstract：:Before extending the application of motor cortex stimulation it is important to investigate the intimate mechanisms by which it alleviates intractable pain and to consider possible side effects. Self-mutilation in animals following extensive neurectomy or posterior rhizotomy of a limb is thought to reveal severe dyses...

journal_title：Neurological research

authors： Pioli EY,Gross CE,Meissner W,Bioulac BH,Bezard E

更新日期：2003-03-01 00:00:00

abstract：:Mountain trekking is significantly increasing in popularity. Hypoxia seems to play a key role in the pathogenesis of acute mountain sickness (AMS). The purpose of this study was to investigate regional cerebral (rSO2) and peripheral (SaO2) oxygen saturation for the first time, during 22 days high altitude trekking (me...

journal_title：Neurological research

authors： Hadolt I,Litscher G

更新日期：2003-03-01 00:00:00

abstract：:We describe the advantages and clarify the technical key points of a microendoscopic, minimally invasive technique to the posterior surgical approach for cervical degenerative disease. The authors studied the microendoscopic posterior approach using the METRx system in both cadaver models and in clinical cases. This n...

journal_title：Neurological research

authors： Yuguchi T,Nishio M,Akiyama C,Ito M,Yoshimine T

更新日期：2003-01-01 00:00:00

abstract：:To investigate the migration of neural stem cells as well as neural plastic changes in epileptic brain, spaciotemporal expression of immunoreactive highly polysialylated neural cell adhesion molecule (PSA-NCAM) was examined in amygdala kindling development of rat. The neural migration and synaptic remodeling detected ...

journal_title：Neurological research

authors： Sato K,Iwai M,Nagano I,Shoji M,Abe K

更新日期：2003-01-01 00:00:00

abstract：:Excessive entry of Ca2+ into injured cochlear neurons activates various Ca(2+)-activated enzymes and subsequent spiral ganglion cell death. Therefore, preventing intracellular calcium overload by using Ca2+ channel antagonists may become an important countermeasure to spiral ganglion cell death. We experimentally inve...

journal_title：Neurological research

authors： Sekiya T,Yagihashi A,Asano K,Suzuki S

更新日期：2002-12-01 00:00:00

abstract：:A 51-year-old man presented with loss of consciousness when he underwent urological examination at another hospital. CT scans showed subarachnoid hemorrhage, and cerebral angiography showed bilateral dissecting aneurysms of the vertebral arteries. Following ventricular drainage, the lesion was managed conservatively w...

journal_title：Neurological research

authors： Matsumoto K,Akagi K,Abekura M,Sakaguchi T

更新日期：2002-12-01 00:00:00

abstract：:This paper describes a previously unreported clinical onset of carcinomatous meningitis with bilateral deafness. Typical changes in the cerebrospinal fluid aside from positive cytology findings are reviewed. In cases of suspected carcinomatous meningitis the clustering of increased CSF protein, lactate, decreased gluc...

journal_title：Neurological research

authors： Zeller JA,Zunker P,Witt K,Schlueter E,Deuschl G

更新日期：2002-10-01 00:00:00

abstract：:We examined whether or not NF-kappaB, a factor that regulates expression of the genes that code for pro-inflammatory cytokines, is activated in cerebrospinal fluid (CSF) cells to investigate the production of pro-inflammatory cytokines by CSF cells in patients with meningitis. Western blotting demonstrated that NF-kap...

journal_title：Neurological research

authors： Ichiyama T,Isumi H,Yoshitomi T,Nishikawa M,Matsubara T,Furukawa S

更新日期：2002-10-01 00:00:00

abstract：:The object of the study was to evaluate brain tissue oxygenation (p(ti)O2) for intra-operative monitoring of critical ischemic events during early cerebral aneurysm surgery of the anterior circulation supplementary to somatosensory evoked potentials (SEPs). P(ti)O2 was continuously evaluated during surgery for an intr...

journal_title：Neurological research

authors： Szelényi A,Jung CS,Schön H,Seifert V

更新日期：2002-09-01 00:00:00

abstract：:Cyclic GMP (cGMP) mediates smooth muscle relaxation in the central nervous system. In subarachnoid hemorrhage (SAH), decreases in intrinsic nitric oxide (NO) cause cerebral vasospasms due to the regulation of cGMP formation by NO-mediated pathways. As phosphodiesterase type V (PDE V) selectively hydrolyzes cGMP, we hy...

journal_title：Neurological research

authors： Inoha S,Inamura T,Ikezaki K,Nakamizo A,Amano T,Fukui M

更新日期：2002-09-01 00:00:00

abstract：:Electrical stimulation of peripheral nerves can be used to cause muscle contraction, to activate reflexes, and to modulate some functions of the central nervous system (neuromodulation). If applied to the spinal cord or nerves controlling the lower urinary tract, electrical stimulation can produce bladder or sphincter...

journal_title：Neurological research

authors： Jezernik S,Craggs M,Grill WM,Creasey G,Rijkhoff NJ

更新日期：2002-07-01 00:00:00

abstract：:Although rat models implanted with C6 glioma cells have been widely utilized for the assessment of new therapeutic modalities, a convenient in vivo model is still required. We implanted C6 glioma cells into the brains and the abdominal subcutaneous regions of Wistar rats, and evaluated the volumes of the growing tumor...

journal_title：Neurological research

authors： Watanabe K,Sakamoto M,Somiya M,Amin MR,Kamitani H,Watanabe T

更新日期：2002-07-01 00:00:00

abstract：:The successful treatment of an intracranial arteriovenous malformation poses both technical and conceptual problems to the neurosurgeon. Treatment decisions are made in light of current understanding of the natural history of these lesions. It is important to understand the pros, cons and current indication of open cr...

journal_title：Neurological research

authors： Surdell DL Jr,Bhattacharjee S,Loftus CM

更新日期：2002-06-01 00:00:00

abstract：:The therapeutic effect of insulin alone or insulin combined with 30 min delayed thrombolytic therapy was investigated in rats embolized in the right hemisphere with a fibrin clot made from autologous blood. Animals were killed seven days after embolization and the infarct volumes were measured in % of the affected hem...

journal_title：Neurological research

authors： Meden P,Andersen M,Overgaard K,Rasmussen RS,Boysen G

更新日期：2002-06-01 00:00:00

abstract：:The anatomical substrates of the perception of motion have not yet been established in a detailed way on an individual level. The aim of this study was to develop a systematic procedure for mapping the visual cortex using Transcranial Magnetic Stimulation (TMS). The results showed that such an individual and detailed ...

journal_title：Neurological research

authors： d'Alfonso AA,van Honk J,Schutter DJ,Caffé AR,Postma A,de Haan EH

更新日期：2002-04-01 00:00:00

abstract：:The present study used immunohistochemistry to investigate p53 expression in rat brain following transient occlusion of the middle cerebral artery. In the control group, no p53-immunoreactive cells were found in any region of the central nervous system. P53 expression in reactive astrocytes was not obvious in the fore...

journal_title：Neurological research

authors： Chung YH,Shin CM,Kim MJ,Lee EY,Kim G,Cha CI

更新日期：2002-04-01 00:00:00

abstract：:We studied brain temperature and the effect of mild hypothermia in 58 patients after severe head injury (SHI). Brain tissue oxygen tension (ptiO2), carbon dioxide tension (ptiCO2), tissuie pH (pHti) and temperature (T.br) were measured using a multiparameter probe. Microdialysis was performed to measure glucose, lacta...

journal_title：Neurological research

authors： Soukup J,Zauner A,Doppenberg EM,Menzel M,Gilman C,Bullock R,Young HF

更新日期：2002-03-01 00:00:00

abstract：:We elected to compare the clinical outcomes of carotid endarterectomy (CEA) patients who were thought to be at increased risk for peri-operative complications because of advanced age (> 79 years), medical comorbidities and contralateral internal carotid artery occlusion to patients without these risk factors. A prospe...

journal_title：Neurological research

authors： Harbaugh RE,Magnadottir HB

更新日期：2002-01-01 00:00:00

abstract：:Traumatic brain injuries (TBIs) are a leading cause of morbidity, mortality, disability and socioeconomic losses in India and other developing countries. Specific topics addressed in this paper include magnitude of the problem, causes, context of injury occurrence, risk factors, severity, outcome and impact of TBIs on...

journal_title：Neurological research

authors： Gururaj G

更新日期：2002-01-01 00:00:00

abstract：:Anesthesia is an essential element during the induction of ischemia/reperfusion and cerebral blood flow (CBF) measurement in most animal models. Cerebral neuroprotection and intrinsic effects on CBF afforded by anesthetics are confounding variables in those models. A new model of global forebrain ischemia/reperfusion ...

journal_title：Neurological research

authors： Melgar MA,Park H,Rafols JA,Diaz FG

更新日期：2002-01-01 00:00:00

abstract：:The endogenous clock of humans can be influenced by light application to the popliteal region. Previously, it had been assumed that light must fall directly into the eye in order to influence the inner circadian clock. This study, published in 1998, has not been reproduced. We investigated the effects of laser light i...

journal_title：Neurological research

authors： Litscher G

更新日期：2001-12-01 00:00:00

abstract：:Although radiation injuries to the brain are well documented, immediate early histological changes in the brain remain to be defined. The present study characterizes glial injury provoked in adult rat white matter within 24 h after a single irradiation of the whole brain (10 or 20 Gray). Irradiated brains were histolo...

journal_title：Neurological research

authors： Kurita H,Kawahara N,Asai A,Ueki K,Shin M,Kirino T

更新日期：2001-12-01 00:00:00

abstract：:No marker that predicts accurately the time of occurrence of cerebral vasospasm due to subarachnoid hemorrhage (SAH) has been reported. In the present study, membrane-bound tissue factor (mTF) and myelin basic protein (MBP) concentrations in cerebrospinal fluid (CSF) were evaluated as a predictor of the time of occurr...

journal_title：Neurological research

authors： Hirashima Y,Endo S,Nakamura S,Kurimoto M,Takaku A

更新日期：2001-10-01 00:00:00

abstract：:Promyelocytic leukemia (PML) protein is involved in apoptotic death of cultured neuronal cells, but its role in ischemic brain damage remains uncertain. In this study, we investigated change of immunoreactivity for PML protein in rat brain after transient middle cerebral artery occlusion, and compared the results with...

journal_title：Neurological research

authors： Hayashi T,Sasaki C,Iwai M,Sato K,Zhang WR,Warita H,Abe K

更新日期：2001-10-01 00:00:00